{"id":26748,"date":"2025-12-19T10:55:38","date_gmt":"2025-12-19T09:55:38","guid":{"rendered":"https:\/\/dev8.id-interactive.fr\/new_unither\/sol-gel-technology\/"},"modified":"2026-02-03T15:52:23","modified_gmt":"2026-02-03T14:52:23","slug":"sol-gel-technology","status":"publish","type":"post","link":"https:\/\/dev8.id-interactive.fr\/new_unither\/sol-gel-technology\/","title":{"rendered":"Sol-Gel technology"},"content":{"rendered":"\r\n
\r\n
\"\"<\/figure>\r\n<\/div>\r\n\r\n\r\n\r\n\r\n\r\n

Unither supports innovation that will benefit patients.<\/strong>\u00a0<\/h2>\r\n\r\n\r\n\r\n

It is in this perspective that we have been collaborating with CNRS, Paris Descartes University and AP-HP since 2012 on Sol-Gel technology.<\/p>\r\n\r\n\r\n\r\n

The Sol-Gel technology is about\u00a0in situ<\/em>\u00a0gel-forming formulations, which\u00a0undergo phase transition from liquid to gel upon exposure\u00a0to physiological environments. This technology combines advantages of being convenient for administration to patients and prolonging\u00a0drug delivery.<\/p>\r\n\r\n\r\n\r\n

So far, 6 international scientific publications dedicated to Sol-Gel technology have been published. You will find below the list of manuscripts that have been published so far. If you are interested in receiving the full version please send an email with your request to:\u00a0unither@unither-pharmaceuticals.com<\/a><\/p>\r\n\r\n\r\n\r\n

\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n
2014<\/strong><\/td>\r\n\u00a0<\/td>\r\nInfluence of additives on a thermosensitive hydrogel for buccal deliveryof salbutamol: Relation Between micellization, gelation, mechanic and release properties<\/td>\r\n<\/tr>\r\n
2015<\/strong><\/td>\r\n\u00a0<\/td>\r\nPoloxamer bioadhesive hydrogel for buccal drug delivery: Cytotoxicity and trans
epithelial permeability evaluations using TR146 human buccal epithelial cell line<\/td>\r\n<\/tr>\r\n
2016<\/strong><\/td>\r\n\u00a0<\/td>\r\nIn\u00a0vitro and in vivo evaluation of in situ gelling systems for sustained topical ophthalmic delivery: state of the art and beyond<\/td>\r\n<\/tr>\r\n
2017<\/strong><\/td>\r\n\u00a0<\/td>\r\nCyanine derivative as a suitable marker for thermosensitive in situ gelling delivery systems: In vitro and in vivo validation of a sustained buccal drug delivery<\/a><\/td>\r\n<\/tr>\r\n
2019<\/strong><\/td>\r\n\u00a0<\/td>\r\nNovel in situ gelling ophthalmic drug delivery system based on gellan gum and hydroxyethylcellulose: Innovative rheological characterization, in vitro and in vivo evidence of a sustained precorneal retention time<\/td>\r\n<\/tr>\r\n
2020<\/strong><\/td>\r\n\u00a0<\/td>\r\nIn Situ Gelling Ophthalmic Drug Delivery System for the Optimization of Diagnostic and Preoperative Mydriasis: In Vitro Drug Release, Cytotoxicity and Mydriasis Pharmacodynamics<\/a><\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>\r\n<\/figure>\r\n\r\n\r\n\r\n

OPHTHALMIC USE<\/h2>\r\n\r\n\r\n\r\n

Unither keeps on working and investing its efforts in ophthalmological research and development, with the main aim of making patients\u2019 lives easier.<\/p>\r\n\r\n\r\n\r\n

Unither\u2019s ophthalmic know-how is expressed through developments on the Coutances and Amiens plants, as well as the laboratories of Bordeaux (France) and Wuhan (China); but also research work on the Sol-Gel technology carried out since 2012\u00a0initiated by Ni Zeng, General Development Manager China and carried on by Pierre-Louis Destruel, former Development Project Manager China.<\/p>\r\n\r\n\r\n\r\n

It took over 3 years of research to deliver the final results on\u00a0the mydriatic sol-gel,<\/strong>\u00a0a novel ocular in situ gelling delivery system designed to \u00a0optimize the induction of diagnostic and preoperative mydriasis<\/strong>. This was made possible thanks to Unither teams and our fruitful collaboration with \u201cAgence G\u00e9n\u00e9rale des Equipements et Produits de Sant\u00e9 (AGEPS) AP-HP\u201d, and \u201cUnit\u00e9 de technologies chimiques et biologiques pour la sant\u00e9, Universit\u00e9 de Paris, CNRS, INSERM, Facult\u00e9 de Pharmacie\u201d<\/p>\r\n\r\n\r\n\r\n

\r\n
https:\/\/www.youtube.com\/watch?v=mvPvz17-lCg<\/div>\r\n<\/figure>\r\n\r\n\r\n\r\n

If you are interested in this article please send us a request at unither@unither-pharma.com<\/p>\r\n","protected":false},"excerpt":{"rendered":"

Unither supports innovation that will benefit patients.\u00a0 It is in this perspective that we have been collaborating with CNRS, Paris Descartes University and AP-HP since 2012 on Sol-Gel technology. The Sol-Gel technology is about\u00a0in situ\u00a0gel-forming formulations, which\u00a0undergo phase transition from liquid to gel upon exposure\u00a0to physiological environments. This technology combines advantages of being convenient for […]<\/p>\n","protected":false},"author":1,"featured_media":20765,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[92],"tags":[],"class_list":["post-26748","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"acf":[],"_links":{"self":[{"href":"https:\/\/dev8.id-interactive.fr\/new_unither\/wp-json\/wp\/v2\/posts\/26748","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dev8.id-interactive.fr\/new_unither\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dev8.id-interactive.fr\/new_unither\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dev8.id-interactive.fr\/new_unither\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dev8.id-interactive.fr\/new_unither\/wp-json\/wp\/v2\/comments?post=26748"}],"version-history":[{"count":1,"href":"https:\/\/dev8.id-interactive.fr\/new_unither\/wp-json\/wp\/v2\/posts\/26748\/revisions"}],"predecessor-version":[{"id":26749,"href":"https:\/\/dev8.id-interactive.fr\/new_unither\/wp-json\/wp\/v2\/posts\/26748\/revisions\/26749"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dev8.id-interactive.fr\/new_unither\/wp-json\/wp\/v2\/media\/20765"}],"wp:attachment":[{"href":"https:\/\/dev8.id-interactive.fr\/new_unither\/wp-json\/wp\/v2\/media?parent=26748"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dev8.id-interactive.fr\/new_unither\/wp-json\/wp\/v2\/categories?post=26748"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dev8.id-interactive.fr\/new_unither\/wp-json\/wp\/v2\/tags?post=26748"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}